Standard Storage Conditions for Lurbinectedin
Lurbinectedin (Zepzelca), an injectable antineoplastic agent, requires refrigeration to maintain stability and prevent degradation or contamination. Store unopened vials at 2°C to 8°C (36°F to 46°F) in a refrigerator. Do not freeze, and protect from light by keeping in original carton.[1][2]
Handling to Prevent Contamination
Inspect vials for damage or particulate matter before use; discard if compromised. Use aseptic technique during preparation: reconstitute only with supplied diluent under a biological safety cabinet. Once reconstituted, use immediately—do not store diluted solution. Any unused portion must be discarded. Avoid contact with skin or mucous membranes; wear protective gear.[1][2]
What If Exposed to Improper Conditions?
If vials exceed 8°C for over 72 hours or drop below 2°C (freezing), discard them to avoid potency loss or contamination risk. Room temperature excursions up to 25°C (77°F) for less than 21 days are acceptable per stability data, but return to refrigeration promptly.[1]
Why These Conditions Matter
Refrigeration slows chemical degradation, while light protection prevents photodegradation. Aseptic handling minimizes microbial entry, critical for IV use in immunocompromised patients.[2]
[1] Zepzelca (lurbinectedin) prescribing information, Jazz Pharmaceuticals, https://www.zepzelca.com/
[2] FDA label for Zepzelca, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213069s000lbl.pdf