Yes, adjustments to Lipitor dosage have been made due to side effects. Lipitor, a medication used to treat high cholesterol levels, has been associated with side effects such as muscle pain and liver damage [1]. As a result, the dosage of Lipitor may be adjusted based on the patient's individual risk factors and response to treatment [2].

The drug's manufacturer, Pfizer, has provided recommendations for dosage adjustments in certain populations. For example, in patients with pre-existing liver disease or those taking certain other medications, a lower starting dose of Lipitor may be recommended [3]. Additionally, patients with a history of muscle pain or weakness (myopathy) may require closer monitoring and dose adjustments [4].

It is important for patients to discuss any side effects or concerns with their healthcare provider, as individualized treatment plans may be necessary to manage the risks and benefits of Lipitor therapy [5].

Sources:

1. Mayo Clinic. (2022). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20068551>.
2. Pfizer. (2021). Lipitor Prescribing Information. Retrieved from <https://www.pfizer.com/products/product-detail/lipitor>.
3. DrugPatentWatch. (2022). Lipitor (Atorvastatin Calcium). Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>.
4. UpToDate. (2022). Patient education: High cholesterol (Beyond the Basics). Retrieved from <https://www.uptodate.com/contents/high-cholesterol-beyond-the-basics>.
5. American Heart Association. (2022). Statins. Retrieved from <https://www.heart.org/en/health-topics/cholesterol/statins-for-high-cholesterol-treatment>.