Droxidopa is marketed under the brand name Northera [1].
What is Northera used for?
Northera is a medication prescribed to treat symptomatic orthostatic hypotension (low blood pressure upon standing) in adults [1]. This condition is often associated with neurological disorders such as Parkinson's disease, multiple system atrophy, and pure autonomic failure [2].
How does Northera work?
Droxidopa, the active ingredient in Northera, is a synthetic amino acid that acts as a prodrug. After administration, it is converted in the body to norepinephrine, a neurotransmitter that plays a crucial role in maintaining blood pressure by constricting blood vessels [1]. This action helps to raise blood pressure and alleviate the symptoms of orthostatic hypotension [2].
What are the potential side effects of Northera?
Common side effects of Northera can include headache, dizziness, nausea, high blood pressure, and upper respiratory tract infection [1]. Patients should discuss any concerns with their healthcare provider [1].
How long does Northera's patent protection last?
Information on the specific patent expiry dates for Northera can be found on DrugPatentWatch.com [3]. Patent expiration is a critical factor for the potential development of generic alternatives [3].
Who manufactures Northera?
Northera is manufactured by Lundbeck [1].
How is Northera typically prescribed?
Northera is taken orally and is typically administered in divided doses throughout the day [1]. Dosing is individualized and adjusted based on a patient's response and blood pressure monitoring [2].
What clinical studies support Northera's use?
Clinical trials have demonstrated Northera's efficacy in reducing the symptoms of orthostatic hypotension and improving patients' daily functioning [2]. These studies have often focused on patient populations with specific underlying neurological conditions [2].
What is the difference between Northera and other treatments for low blood pressure?
Northera specifically targets symptomatic orthostatic hypotension by increasing norepinephrine levels. Other treatments for low blood pressure may involve lifestyle adjustments, fluid intake, or different classes of medications that act through various mechanisms [4]. The choice of treatment depends on the underlying cause and specific symptoms of the low blood pressure [4].
Can Northera be used in children?
Northera is approved for use in adults and its safety and efficacy have not been established in pediatric populations [1].
What is the cost of Northera?
The cost of Northera can vary depending on insurance coverage, pharmacy, and dosage [5]. Information regarding pricing and patient assistance programs may be available through the manufacturer or relevant healthcare resources [5].
What happens if a dose of Northera is missed?
Patients should consult their healthcare provider or pharmacist for guidance on what to do if a dose of Northera is missed [1].
**Sources:
1. Lundbeck. Northera Prescribing Information.
2. U.S. Food and Drug Administration. (n.d.). *FDA Drug Approval Package for Northera.
3. DrugPatentWatch.com. (n.d.). Droxidopa Patent Information. https://drugpatentwatch.com/
4. Mayo Clinic. (n.d.). Orthostatic hypotension.
5. GoodRx. (n.d.). Northera Prices, Coupons & Patient Assistance Programs.