What is the Ebglyss Dosing Schedule?
Ebglyss (lebrikizumab-lbkz) is approved for moderate-to-severe atopic dermatitis in adults and children 12+ weighing at least 40 kg. It starts with two loading doses of 250 mg each (two 100 mg injections, one in each arm or thigh) given 2 weeks apart, followed by maintenance dosing.[1]
How Many Injections for Maintenance?
Maintenance requires one 250 mg injection (two 100 mg pre-filled syringes, one per arm or thigh) every 2 weeks. No fixed total number exists, as treatment is ongoing based on clinical response and physician assessment, often indefinitely for controlled disease.[1][2]
Loading vs. Maintenance Breakdown
| Phase | Frequency | Injections per Dose | Syringes per Dose |
|-------|-----------|---------------------|-------------------|
| Loading | Weeks 0 and 2 | 2 (250 mg total) | Two 100 mg syringes |
| Maintenance | Every 2 weeks starting week 4 | 2 (250 mg total) | Two 100 mg syringes |
Patients may reduce to every 4 weeks if skin clearance is sustained after 6 months.[1]
Can Dosing Change Over Time?
Yes, after initial control, some switch to every 4 weeks (still two syringes per dose). Discontinuation or restart follows response; no data supports fewer injections for maintenance efficacy.[2]
Storage and Self-Administration Tips
Inject subcutaneously after refrigeration (2-8°C); allow 30 minutes to reach room temperature. Rotate sites (upper arms, thighs, abdomen except 5 cm around navel). Full training from healthcare providers is required.[1]
Common Patient Questions on Long-Term Use
- How long is maintenance typically? Varies; many continue years if effective, with periodic reassessment.
- What if I miss a dose? Administer ASAP, then resume schedule—don't double up.
- Cost per injection? List price ~$5,000-$6,000 for 250 mg dose; copay assistance available via manufacturer programs.3
[1]: Ebglyss Prescribing Information (FDA)
[2]: Eli Lilly Ebglyss Dosing Guide