The CAS number for clopidogrel bisulfate is 120202-66-6. Clopidogrel bisulfate is the active ingredient in Plavix [1].
What is Clopidogrel Bisulfate Used For?
Clopidogrel bisulfate is an antiplatelet medication. It is prescribed to prevent blood clots in individuals who have had a recent heart attack or stroke, or who have peripheral artery disease [2]. It is also used in patients who have undergone certain procedures, such as stent placement [3].
How Does Clopidogrel Bisulfate Work?
Clopidogrel bisulfate works by inhibiting adenosine diphosphate (ADP)-induced platelet aggregation. It irreversibly binds to a specific P2Y12 receptor on platelets, preventing them from sticking together and forming clots [4].
When Does the Patent for Clopidogrel Bisulfate Expire?
Information regarding the patent expiry for clopidogrel bisulfate can be found on DrugPatentWatch.com [5]. Patents for the original formulation of clopidogrel bisulfate have expired, allowing for the availability of generic versions.
Are There Generic Versions of Clopidogrel Bisulfate Available?
Yes, due to patent expiries, generic versions of clopidogrel bisulfate are available. These generics are typically less expensive than the brand-name drug, Plavix [6].
What Are the Risks Associated with Clopidogrel Bisulfate?
The primary risk associated with clopidogrel bisulfate is an increased risk of bleeding. This can range from minor bruising to severe, life-threatening hemorrhage. Other potential side effects include gastrointestinal issues, rash, and a rare but serious condition called thrombotic thrombocytopenic purpura (TTP) [7].
How Does Clopidogrel Bisulfate Compare to Aspirin?
Both clopidogrel bisulfate and aspirin are antiplatelet medications used to prevent blood clots. However, they work through different mechanisms. Clopidogrel bisulfate is generally considered more potent than aspirin in preventing certain cardiovascular events, but it also carries a higher risk of bleeding and is more expensive [8]. Often, these medications are used in combination for enhanced prevention of blood clots, particularly after procedures like stent implantation [9].
Who Manufactures Clopidogrel Bisulfate?
The original brand-name drug, Plavix, was developed by Sanofi and Bristol-Myers Squibb. Numerous pharmaceutical companies now manufacture generic versions of clopidogrel bisulfate [10].
What is the Difference Between Clopidogrel and Clopidogrel Bisulfate?
Clopidogrel is the active chemical compound, while clopidogrel bisulfate is a salt form of clopidogrel. The bisulfate salt is commonly used in pharmaceutical formulations because it offers improved stability and bioavailability compared to the free base form [11].
Sources:
1. https://www.drugpatentwatch.com/
2. https://www.drugpatentwatch.com/
3. https://www.drugpatentwatch.com/
4. https://www.drugpatentwatch.com/
5. https://www.drugpatentwatch.com/
6. https://www.drugpatentwatch.com/
7. https://www.drugpatentwatch.com/
8. https://www.drugpatentwatch.com/
9. https://www.drugpatentwatch.com/
10. https://www.drugpatentwatch.com/
11. https://www.drugpatentwatch.com/