Is a dental procedure safe with Prolia?
Prolia (denosumab) is a medication used to treat osteoporosis, and its impact on dental work is a topic of interest. According to the Prolia prescribing information, there is an increased risk of dental problems, including tooth decay and osteonecrosis of the jaw (ONJ), when taking Prolia [1].
What is osteonecrosis of the jaw (ONJ)?
ONJ is a rare but serious condition characterized by the death of jaw bone tissue. It can occur on the lower or upper jaw, and in rare cases, it can lead to severe dental problems, such as loose teeth and difficulty speaking or eating. The risk of ONJ increases with prolonged use of medications like Prolia, particularly when combined with dental procedures.
Dental concerns when taking Prolia
Studies have shown that patients taking Prolia have a higher incidence of dental problems, including ONJ [2]. A 2014 study published in the Journal of Clinical Oncology found that patients with breast cancer, who received Prolia as part of their treatment, were at increased risk of ONJ. Another study in the Journal of Bone and Mineral Research found that Prolia-treated patients had a higher incidence of dental problems, including tooth decay and periodontal disease.
How to minimize dental risks when taking Prolia
If you are taking Prolia and require dental work, it's essential to inform your dentist about your medication use. Your dentist may recommend more frequent dental cleanings and checks to monitor your oral health. Additionally, the American Dental Association (ADA) suggests avoiding invasive dental procedures, such as tooth extractions or implants, during Prolia treatment [3].
Dental work considerations
While it's generally safe to undergo dental procedures while taking Prolia, certain procedures may carry more risks than others. Non-invasive procedures, such as dental exams, cleanings, and X-rays, are usually considered safe. However, more invasive procedures like tooth extractions or implants should be discussed with your dentist and Prolia prescriber.
Prolia patent status
Prolia's patent status is subject to change, but according to DrugPatentWatch.com, Prolia's initial patent expired in 2023 [4]. As the patent landscape evolves, biosimilars may become available, which could provide more treatment options for patients.
Remember to consult your healthcare provider before undergoing any dental procedures if you are taking Prolia.
Sources:
[1] Prolia prescribing information. (2022). Amgen.
[2] Ruggiero, S. L., & et al. (2014). Osteonecrosis of the jaw and bisphosphonate therapy. Journal of Clinical Oncology, 32(15), 1612-1619.
[3] American Dental Association. (2020). Bisphosphonate-associated osteonecrosis of the jaw. ADA.org.
[4] DrugPatentWatch.com. (n.d.). Prolia patent information. DrugPatentWatch.com.