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See the DrugPatentWatch profile for Fomivirsen
Yes. Fomivirsen, ISIS 2922, and Vitravene all refer to the same drug. - What it is: Fomivirsen is an antisense oligonucleotide developed by Isis Pharmaceuticals (now Ionis) for CMV infections. - Brand/name codes: ISIS 2922 is the development code; Vitravene is the brand name. - Indication: Used to treat CMV retinitis in immunocompromised patients (historically in AIDS patients). - Mechanism of action: An antisense oligonucleotide that binds to CMV mRNA and blocks its translation, inhibiting viral replication. - Route of administration: Given by intravitreal injection (injected into the eye) by an ophthalmologist. - Practical notes: It was the first antisense drug approved by the FDA (1998). In practice, it has been far less commonly used since other systemic anti-CMV therapies (e.g., ganciclovir, valganciclovir) and evolving treatments have become more prevalent. Potential ocular risks include local injection-site reactions, conjunctival hemorrhage, endophthalmitis, and retinal detachment. If you want, I can provide more detail on mechanism, dosing/regimens, or adverse effects.
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