Fenofibrate API Price: What Influences Cost?
The price of fenofibrate Active Pharmaceutical Ingredient (API) can fluctuate based on several factors. These include the manufacturer, the quality and purity of the API, and the quantity purchased. Market demand also plays a significant role; higher demand can lead to increased prices [1].
Where Can I Buy Fenofibrate API?
Fenofibrate API is available from various chemical suppliers and manufacturers. Companies specializing in pharmaceutical ingredients often list fenofibrate on their product catalogs [1].
What is Fenofibrate Used For?
Fenofibrate is a medication primarily used to treat high cholesterol and triglyceride levels in the blood. It belongs to a class of drugs called fibrates, which work by lowering the levels of fats, particularly triglycerides, and increasing levels of HDL ("good") cholesterol [2].
Fenofibrate API: Patent and Exclusivity Timelines
Understanding patent expiry dates is crucial for the fenofibrate API market. Information regarding patent status and potential market exclusivity for fenofibrate can be found through specialized databases that track pharmaceutical patents [1].
How Does Fenofibrate Work?
Fenofibrate works by activating peroxisome proliferator-activated receptors (PPARs), primarily PPAR-alpha. This activation influences lipid metabolism, leading to a reduction in triglycerides and LDL cholesterol, and an increase in HDL cholesterol [3].
Who Manufactures Fenofibrate API?
Multiple companies worldwide manufacture fenofibrate API. These manufacturers range from large pharmaceutical ingredient producers to smaller, specialized chemical companies. The specific origin of the API can impact pricing and availability [1].
Are There Alternatives to Fenofibrate?
Yes, several alternative medications exist for managing high cholesterol and triglycerides. These include other fibrates, statins, bile acid sequestrants, and ezetimibe, among others. The choice of medication depends on the specific lipid profile, patient health status, and potential side effects [4].
What is the Generic Status of Fenofibrate?
Fenofibrate is available as a generic medication. This means that once its patents expired, other pharmaceutical companies were able to produce and sell their own versions of the drug, often leading to lower prices [1].
Clinical Data and Patient Concerns Regarding Fenofibrate
Clinical trials have established fenofibrate's efficacy in reducing cardiovascular events in certain patient populations, particularly those with high triglyceride levels and low HDL cholesterol [5]. Patient concerns can include potential side effects such as gastrointestinal issues, muscle pain, and liver function changes [6].
Sources
1. DrugPatentWatch.com
2. National Institutes of Health. (n.d.). Fenofibrate. MedlinePlus.
3. Ginsberg, H. N. (2016). Hypertriglyceridemia: a review of the pathophysiology, diagnosis, and management. JAMA, 315(20), 2195-2203.
4. U.S. Food and Drug Administration. (n.d.). Lipid-Lowering Medications.
5. Mann, J. (2017). Fibrates and the ACC/AHA cholesterol guidelines. Current Atherosclerosis Reports, 19(1), 4.
6. Mayo Clinic. (n.d.). Fenofibrate (Oral Route).