How many humira injections are in the first dose?

What Is the First Humira Dose?

Humira (adalimumab) loading doses vary by condition. For most adults with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or Crohn's disease, the first dose is 40 mg (one prefilled syringe or pen) given as a single subcutaneous injection.[1]

Doses for Other Conditions

• Ulcerative colitis or plaque psoriasis in adults: Also 40 mg as one injection.
  
• Pediatric patients (under 18, e.g., juvenile idiopathic arthritis): Often two 20 mg/0.4 mL injections (total 40 mg), especially for those 15 kg to <30 kg.[1][2]
  
• Hidradenitis suppurativa: Starts with 160 mg total over two days (four 40 mg injections), then maintenance.[1]
  
  

Why Might It Involve Multiple Injections?

Loading doses for some indications like hidradenitis suppurativa or pediatric uveitis use multiple 40 mg or 20 mg pens/syringes to reach the target dose, administered at different sites to minimize irritation.[2]

Injection Devices and Storage

Each Humira pen or syringe holds one dose (typically 40 mg/0.8 mL or 20 mg/0.4 mL). The first dose uses 1–4 units depending on weight, condition, and protocol. Store refrigerated; let warm to room temperature before injecting.[1]

[1]: Humira Prescribing Information (AbbVie)
[2]: Drugs.com - Humira Dosage Guide