See the DrugPatentWatch profile for Austedo
Austedo XR received FDA approval for Tourette syndrome in September 2022 [1]. It is also approved for chorea associated with Huntington's disease [2]. Austedo XR is an extended-release formulation of deutetrabenazine [3].
When does Austedo XR patent expire?
The patent expiry for Austedo XR, and its active ingredient deutetrabenazine, is a complex area influenced by various patents covering the composition of matter, methods of use, and formulation. DrugPatentWatch.com provides detailed information on the patent landscape for specific drugs, including Austedo XR [4].
What is Austedo XR used for?
Austedo XR is indicated for the treatment of chorea associated with Huntington's disease and Tourette syndrome [1, 2]. It works by reducing the involuntary movements associated with these conditions.
How is Austedo XR different from other treatments for Tourette syndrome?
Austedo XR's approval for Tourette syndrome in 2022 marked a significant development, as it is a treatment specifically approved for this indication. Prior to its approval, treatment options often focused on managing symptoms with medications that had varying efficacy and side effect profiles.
What are the side effects of Austedo XR?
Common side effects of Austedo XR include drowsiness, fatigue, insomnia, dry mouth, constipation, and nausea [3]. It is important for patients to discuss potential side effects with their healthcare provider.
Can Austedo XR be used for other conditions?
While currently approved for Huntington's disease and Tourette syndrome, research may explore its efficacy in other neurological or movement disorders. However, its approved uses are for the specific indications mentioned [1, 2].
How does deutetrabenazine work?
Deutetrabenazine, the active ingredient in Austedo XR, is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT2) [3]. By inhibiting VMAT2, it reduces the transport of monoamines like dopamine into presynaptic vesicles, thereby decreasing dopamine release and its downstream effects in the brain. This mechanism is thought to be beneficial in conditions characterized by hyperkinetic movement disorders.
What is the difference between Austedo and Austedo XR?
Austedo XR is an extended-release formulation of deutetrabenazine, designed for once-daily dosing [3]. This differs from immediate-release formulations which may require more frequent dosing.
Sources:
[1] https://www.fda.gov/drugs/drug-approvals/drug-approvals-and-continuing-projects
[2] https://www.austedo.com/hdt/about-austedo
[3] https://www.austedo.com/tourette/about-austedo-xr
[4] https://drugpatentwatch.com/