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See the DrugPatentWatch profile for saxagliptin
Saxagliptin and sitagliptin are both DPP-4 inhibitors used to manage type 2 diabetes by helping the pancreas release more insulin and reducing glucose output from the liver. How does saxagliptin compare with sitagliptin in clinical trials? Clinical studies show similar blood sugar reductions, with saxagliptin achieving an A1C drop of roughly 0.7% and sitagliptin achieving 0.6–0.7%. What side effects are patients asking about? Both drugs share a risk of joint pain and pancreatitis, but saxagliptin has a higher reported association with heart failure hospitalization in some analyses. When does saxagliptin patent expire? Saxagliptin patents held by Bristol-Myers Squibb and AstraZeneca expire in 2024, while sitagliptin is already off-patent in the generic versions available.
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