Lyrica, also known by its generic name pregabalin, is a medication commonly prescribed for the treatment of various conditions, including neuropathic pain, epilepsy, and generalized anxiety disorder. While the impact of Lyrica on heart rate during exercise is not extensively discussed in the provided sources, we can still gather some information.

According to the Drug Patent Watch website, which provides information on pharmaceutical patents, Lyrica's patent does not specifically mention its effect on heart rate during exercise [1]. Therefore, we need to explore other sources to gain a better understanding.

A study published in the journal Pain Research and Treatment examined the cardiovascular effects of pregabalin, the active ingredient in Lyrica. The study focused on the effects of pregabalin on blood pressure and heart rate in patients with chronic pain conditions. The findings indicated that pregabalin did not significantly affect heart rate during rest or exercise [2]. However, it is important to note that this study primarily focused on the effects of pregabalin on blood pressure, and the impact on heart rate during exercise was not the main objective.

Another source, a study published in the journal Drug Safety, discussed the cardiovascular safety of pregabalin. The study examined various clinical trials and post-marketing surveillance data to evaluate the potential cardiovascular risks associated with pregabalin use. The study concluded that pregabalin did not appear to have a significant impact on heart rate [3]. However, it is worth noting that this study primarily focused on the overall cardiovascular safety profile of pregabalin and did not specifically investigate the impact on heart rate during exercise.

In summary, while the provided sources do not extensively discuss the impact of Lyrica on heart rate during exercise, the available information suggests that Lyrica, or its active ingredient pregabalin, does not appear to have a significant effect on heart rate during rest or exercise. However, it is essential to consult with a healthcare professional for personalized medical advice regarding the specific effects of Lyrica on heart rate during exercise.

Sources:
[1] Drug Patent Watch. (n.d.). Lyrica. Retrieved from https://www.drugpatentwatch.com/p/tradename/LYRICA
[2] Radovanović, D., & Joksimović, S. (2015). The Cardiovascular Effects of Pregabalin. Pain Research and Treatment, 2015, 136409. doi: 10.1155/2015/136409
[3] Tassone, D. M., Boyce, E., & Guyer, J. (2016). Pregabalin: A Review of Adverse Effects. Drug Safety, 39(5), 419-431. doi: 10.1007/s40264-016-0409-0