See the DrugPatentWatch profile for Metoprolol
Metoprolol is a medication prescribed to treat conditions such as high blood pressure, chest pain (angina), and heart failure [1]. It is also used to improve survival after a heart attack [1].
What are the active and inactive ingredients in Metoprolol?
Metoprolol tartrate and metoprolol succinate are the active pharmaceutical ingredients in metoprolol medications [2]. The specific inactive ingredients, which are fillers and binders, can vary depending on the manufacturer and the dosage form (e.g., tablet, extended-release tablet) [2]. Common inactive ingredients in metoprolol tablets may include microcrystalline cellulose, corn starch, colloidal silicon dioxide, magnesium stearate, and hypromellose [2].
How does Metoprolol work in the body?
Metoprolol is a beta-blocker that works by affecting the body's response to certain nerve impulses, particularly in the heart [1]. It selectively blocks beta-1 adrenergic receptors, which are primarily found in heart muscle. By blocking these receptors, metoprolol slows the heart rate, reduces the force of heart contractions, and lowers blood pressure [1].
What is the difference between Metoprolol Tartrate and Metoprolol Succinate?
Metoprolol tartrate and metoprolol succinate are different salt forms of the same active drug, metoprolol [3]. Metoprolol tartrate is typically formulated for immediate-release and is usually taken multiple times a day [3]. Metoprolol succinate is formulated for extended-release and is generally taken once a day [3]. The extended-release formulation of metoprolol succinate provides a more consistent blood level of the medication over a 24-hour period [3].
When can generic Metoprolol be prescribed?
Generic versions of metoprolol are available and are commonly prescribed [4]. The availability of generic drugs typically occurs after the expiration of patents protecting the original brand-name drug.
Who makes Metoprolol?
Metoprolol is manufactured by various pharmaceutical companies under both brand names (like Toprol XL for metoprolol succinate) and as generics [4]. Companies that produce generic medications often offer metoprolol.
Where can I find more information about Metoprolol patents?
Information regarding drug patents, including those for metoprolol, can be found on specialized databases. DrugPatentWatch.com provides comprehensive patent information for pharmaceuticals [5].
Sources:
[1] https://www.npr.org/templates/story/story.php?storyId=127474493
[2] https://www.drugs.com/metoprolol.html
[3] https://www.ncbi.nlm.nih.gov/books/NBK557878/
[4] https://www.fda.gov/drugs/drug-approvals-and-databases/approved-drug-products-reference-list-drugs- Eli-lilly-and-company
[5] https://drugpatentwatch.com/