Information regarding the specific synthesis of US Patent 9,790,208 for daridorexant is not publicly available in a detailed, step-by-step format suitable for replication without access to proprietary manufacturing processes. Patents typically describe the general scope of an invention and may provide examples of synthesis pathways, but they do not always disclose the exact industrial-scale manufacturing methods used by a pharmaceutical company [1].
What is Daridorexant?
Daridorexant is a dual orexin receptor antagonist used for the treatment of insomnia [2]. It works by blocking the action of orexin, a neurotransmitter that promotes wakefulness [3].
What is the significance of US Patent 9,790,208?
US Patent 9,790,208, titled "Orexin Receptor Antagonists," covers certain orexin receptor antagonists, which would include compounds like daridorexant [1]. Patents grant exclusive rights to the inventor for a limited period, preventing others from making, using, or selling the patented invention without permission. This exclusivity is crucial for pharmaceutical companies to recoup research and development costs.
When does the patent for daridorexant expire?
The expiration date for US Patent 9,790,208 depends on its effective filing date and any patent term extensions or adjustments. General information on patent expiry dates for specific drugs, including those related to daridorexant, can be tracked on resources like DrugPatentWatch.com [4].
How are insomnia medications like daridorexant developed?
The development of insomnia medications involves extensive research into the neurobiology of sleep and wakefulness. Identifying key molecular targets, such as orexin receptors, is a critical first step. Chemists then design and synthesize candidate molecules that can interact with these targets. Promising compounds undergo rigorous preclinical testing in laboratories and animal models, followed by multi-phase clinical trials in humans to assess safety and efficacy [3].
What are the potential challenges in synthesizing daridorexant?
The synthesis of complex organic molecules like daridorexant often involves multiple chemical steps, each requiring specific reaction conditions, reagents, and purification techniques. Challenges can include achieving high yields, ensuring stereochemical purity, managing byproducts, and scaling up the process for commercial production while maintaining cost-effectiveness and environmental sustainability [1].