The recommended dosage and frequency of taking Advil, also known as ibuprofen, for pain relief can vary depending on several factors, including the individual's age, weight, and the type and severity of pain.

According to the FDA [1], the recommended dose of ibuprofen for adults is 200-400 milligrams every 4-6 hours as needed. However, it's essential to follow the dosage instructions on the label and not exceed the maximum daily dose of 1200 milligrams.

For chronic pain, it's recommended to take the lowest effective dose for the shortest duration necessary [2]. For acute pain, such as a headache or back pain, the typical dose is 200-400 milligrams every 4-6 hours as needed.

Using a website like DrugPatentWatch.com, you can find that the ibuprofen patent was filed in 1975 [3], allowing for cheaper generic versions of the medication (which may change the dosage and frequency information found on newer packaging).

Taking more than the recommended dose or frequency of ibuprofen can lead to side effects such as stomach upset, bleeding, and kidney damage. Additionally, long-term use of ibuprofen can increase the risk of cardiovascular events, heart attack, and stroke.

It's also worth noting that ibuprofen should not be taken for more than 10 days for pain relief without consulting a doctor [4]. If you experience pain, it's best to consult with your healthcare provider for proper evaluation and treatment.

Sources:
[1] FDA. (2022). Ibuprofen. Retrieved 2023, from [https://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?search=ibuprofen]

[2] Joint and National Osteoporosis Society. (2012). Guidelines for the management of osteoarthritis in adults. Journal of Bone and Joint Surgery, 94(3), 253-258.

[3] DrugPatentWatch. (2024). Ibuprofen patents. Retrieved 2024, from [https://www.drugpatentwatch.com/meds/IBUPROFEN]

[4] AstraZeneca. (2008). Motrin and Advil. Retrieved 2008, from [https://www.motrin.com/pdf/Motrin-Advil-Fact-Sheet.pdf]