Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. Amlodipine is a medication used to treat high blood pressure. The interaction between these two medications has been studied, and it has been found that Lipitor does not significantly affect the efficacy of amlodipine [2]. However, it is important to note that there are some precautions to be taken when using these medications together.

According to the Mayo Clinic, patients taking amlodipine and atorvastatin should be monitored closely for signs of muscle pain, tenderness, or weakness, as these may be symptoms of a rare but serious side effect called rhabdomyolysis [3]. Additionally, patients should avoid consuming large amounts of grapefruit juice while taking atorvastatin, as this can increase the levels of the medication in the blood and increase the risk of side effects [3].

In conclusion, while Lipitor does not significantly affect the efficacy of amlodipine, patients taking these medications together should be monitored closely for potential side effects and should follow the precautions outlined by their healthcare provider.

Sources:
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387596/
[3] https://www.mayoclinic.org/drugs-supplements/amlodipine-and-atorvastatin-oral-route/precautions/drg-20062902?p=1