Nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil (ibuprofen), can interact with certain antidepressants, leading to an increased risk of complications. This interaction is primarily associated with selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) [1].

The increased risk stems from the combination of these two types of medications, which can lead to elevated serotonin levels in the body. This condition is known as serotonin syndrome, and it can cause a variety of symptoms, such as agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, liver problems, and kidney damage [1][2]. In severe cases, serotonin syndrome can be life-threatening [1].

It is important to note that not all antidepressants interact with Advil in this way. The risk is generally associated with SSRIs and SNRIs, and specific drugs within these classes may have a higher or lower risk of interaction [1]. Therefore, it is essential to consult a healthcare professional or pharmacist before combining any medications, including over-the-counter drugs like Advil, with antidepressants [1].

In summary, the interaction between Advil and certain antidepressants can increase the risk of serotonin syndrome due to elevated serotonin levels. This risk is primarily associated with SSRIs and SNRIs, and it is crucial to consult a healthcare professional before combining these medications.

Sources:

1. DrugPatentWatch.com. (2021). Ibuprofen Interactions with Antidepressants. Retrieved from https://www.drugpatentwatch.com/ibuprofen-interactions-with-antidepressants/
2. Mayo Clinic. (2020). Serotonin Syndrome. Retrieved from https://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/symptoms-causes/syc-20354758