Flexeril, a muscle relaxant, was discontinued due to concerns regarding its side effects, particularly those affecting the central nervous system [1].
What were the side effects of Flexeril?
Flexeril (cyclobenzaprine) was known to cause drowsiness and dizziness, which could impair a person's ability to operate machinery or drive [1]. Other reported side effects included dry mouth, fatigue, and blurred vision [1]. In some cases, more serious side effects like confusion, hallucinations, and irregular heartbeats were observed [1].
When was Flexeril discontinued?
Flexeril was withdrawn from the market in the United States in March 2012 [2]. This action was taken voluntarily by the manufacturer, Penederm Inc., in coordination with the U.S. Food and Drug Administration (FDA) [2].
What replaced Flexeril?
Following the discontinuation of Flexeril, cyclobenzaprine remained available in generic formulations [3]. Patients and healthcare providers transitioned to these generic versions, which are chemically identical to the original brand-name drug [3].
Can cyclobenzaprine cause liver problems?
While not the primary reason for Flexeril's discontinuation, there have been rare reports of liver injury associated with cyclobenzaprine use [4]. These instances were idiosyncratic and not dose-dependent, meaning they occurred unpredictably and regardless of the amount of medication taken [4].
Are there other muscle relaxants available?
Yes, several other muscle relaxants are available for treating muscle spasms and associated pain. These include medications like carisoprodol, methocarbamol, and baclofen, each with its own profile of efficacy and potential side effects [5].
Sources:
1. DrugPatentWatch.com
2. FDA News Release
3. US Pharmacist
4. Hepatology International
5. Mayo Clinic