Based on the available information, it is possible for certain vitamin supplements to interact with Lipitor, a medication commonly prescribed to lower cholesterol levels. According to Medical News Today, specific drugs, including Lipitor (atorvastatin), can interact with grapefruit juice, St. John's wort, and red yeast rice [${3}].

Red yeast rice, a dietary supplement, contains monacolin K, which is a statin similar to atorvastatin (Lipitor) [${3}]. Consuming red yeast rice alongside Lipitor may increase the risk of side effects related to muscle and liver damage [${3}].

St. John's wort, a herbal supplement used to treat depression, can decrease the effectiveness of Lipitor by speeding up the body's metabolism of the medication [${3}].

Grapefruit juice can interact with Lipitor by affecting how the body absorbs and breaks down the drug [${2}]. This interaction may increase the concentration of Lipitor in the blood, potentially leading to side effects such as muscle pain and liver damage [${2}].

Although the Drug Patent Watch page on Vitamin does not directly mention Lipitor interactions with vitamin supplements, it does list various drug interactions with vitamins [${1}].

In summary, specific vitamin supplements, such as red yeast rice, St. John's wort, and substances like grapefruit juice, can interact with Lipitor and potentially lead to increased side effects or reduced drug effectiveness [${1}, ${2}, ${3}]. Always consult a healthcare professional before combining medications and supplements.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/VITAMIN>
[2] <https://www.medicalnewstoday.com/articles/drugs-lipitor-interactions>
[3] <https://www.singlecare.com/blog/atorvastatin-interactions/>