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See the DrugPatentWatch profile for Nitrofurantoin
Do you mean nitrofurantoin monohydrate/macrocrystals (the combination product often labeled as nitrofurantoin), or nitrofurantoin monohydrate alone, or nitrofurantoin macrocrystals? The term you typed (“nitrofurantoin monomcr”) looks like a misspelling. Here’s a quick, generic overview while we sort out the exact form: - What it is: Nitrofurantoin is an antibiotic used mainly for uncomplicated urinary tract infections caused by susceptible bacteria. - Forms and how they’re dosed (typical adult options; exact dose depends on the product): - Nitrofurantoin monohydrate/macrocrystals (commonly called Macrodantin/Macrobid in the past, but dosing depends on the exact product): different products have different dosing schedules. - Nitrofurantoin macrocrystals (Macrodantin): usually taken every 6 hours (q6h) for about 7 days. - Nitrofurantoin monohydrate (often marketed as Macrobid in the US): commonly 100 mg twice daily (every 12 hours) for about 5 days. - Nitrofurantoin suspension (for kids or others who can’t swallow capsules). - Indications: - Acute uncomplicated cystitis in non-pregnant adults. - Prophylaxis for recurrent UTIs in some cases. - Not appropriate for pyelonephritis or bloodstream infections. - Important safety notes: - Not recommended if creatinine clearance is very low (reduced kidney function); generally avoided with significant renal impairment. - Not recommended near term in pregnancy (late pregnancy) and usually avoided in newborns, especially in babies <1 month old. - Can cause allergic reactions; can cause brown urine. - Rare but serious: lung (pulmonary) reactions, liver injury, and hemolytic anemia in people with G6PD deficiency. - Interactions: probenecid can raise nitrofurantoin levels; some antacids or other drugs can affect absorption. If you can tell me the exact product name or share the label dose you’re looking at (for example, Macrobid 100 mg capsules, or Macrodantin 50 mg/100 mg tabs, etc.), I can give you a precise dosing summary and more specific safety notes.
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