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Why do some patients report blood pressure changes while taking Lipitor? Some patients notice blood pressure changes while taking Lipitor (atorvastatin) because cholesterol levels affect blood vessel stiffness. When cholesterol builds up in artery walls, vessels become less elastic. Atorvastatin reduces LDL cholesterol, which can improve vessel flexibility over time. This may lead to modest blood pressure reductions in certain patients. [1] How does Lipitor affect blood pressure differently than dedicated blood pressure medications? Lipitor does not act like a dedicated blood pressure drug. It belongs to the statin class and works primarily by blocking HMG-CoA reductase to sen
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