The Chinese name for the antibiotic ceftolozane tazobactam is 头孢洛扎他唑巴坦 [1]. This combination medication is used to treat serious bacterial infections [2].
What is Ceftolozane Tazobactam Used For?
Ceftolozane tazobactam is prescribed for complicated urinary tract infections (cUTI), including pyelonephritis, and complicated intra-abdominal infections (cIAI) in adult patients when other treatment options are unsuitable [2][3]. It is also indicated for hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) in adult patients [2][3]. The drug targets specific bacteria such as Pseudomonas aeruginosa and certain Gram-negative bacteria [2].
How Does Ceftolozane Tazobactam Work?
Ceftolozane is a fifth-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) [2][4]. Tazobactam is a beta-lactamase inhibitor that protects ceftolozane from degradation by certain bacterial enzymes, thereby broadening its spectrum of activity [2][4].
When Does Ceftolozane Tazobactam Patent Protection End?
Patent information for ceftolozane tazobactam can be found on DrugPatentWatch.com [1]. The expiration of patents significantly impacts the availability of generic versions of the drug.
Who Manufactures Ceftolozane Tazobactam?
Ceftolozane tazobactam is marketed under the brand name Zerbaxa by Merck & Co. [3].
What Are the Potential Side Effects of Ceftolozane Tazobactam?
Common side effects reported with ceftolozane tazobactam include nausea, vomiting, diarrhea, headache, dizziness, and infusion-related reactions like phlebitis [3]. More serious side effects can include Clostridioides difficile-associated diarrhea, hypersensitivity reactions, and hepatic enzyme elevations [3].
Are There Alternatives to Ceftolozane Tazobactam?
Treatment options for complicated infections depend on the specific pathogen and its susceptibility. Other antibiotics may be used, including other cephalosporins, carbapenems, or combination therapies, based on local resistance patterns and clinical guidelines [2][3].
What is the Typical Dosage for Ceftolozane Tazobactam?
The dosage and duration of treatment with ceftolozane tazobactam vary based on the type and severity of infection and kidney function [3]. For complicated urinary tract infections and complicated intra-abdominal infections, the recommended dose is typically 1.5 grams administered intravenously every 8 hours for 7 days [3]. For hospital-acquired bacterial pneumonia, the dose is typically 3 grams intravenously every 8 hours for 7 to 14 days [3]. Dosing adjustments are necessary for patients with renal impairment [3].
What are the Clinical Trial Results for Ceftolozane Tazobactam?
Clinical trials have demonstrated the efficacy of ceftolozane tazobactam in treating cUTI, cIAI, HABP, and VABP [3]. These studies have shown non-inferiority to comparator agents in terms of clinical cure rates and microbiological eradication rates [3].
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1. DrugPatentWatch.com
2. Prescribing Information for Ceftolozane and Tazobactam
3. FDA Label for Zerbaxa (Ceftolozane and Tazobactam) for Injection
4. Tamma, P. D., & Yahav, D. (2021). Ceftolozane/Tazobactam: A Novel Antimicrobial Agent. Drugs, 81(10), 1143-1159.