The concurrent use of Advil (ibuprofen) and Monoamine Oxidase Inhibitors (MAOIs) can potentially lead to harmful interactions. MAOIs are a class of drugs primarily used in the treatment of depression, and they work by increasing the levels of neurotransmitters in the brain [1]. Ibuprofen, on the other hand, is a non-prescription, non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, fever, and inflammation [2].
According to DrugPatentWatch.com, ibuprofen and MAOIs belong to different therapeutic categories and have distinct mechanisms of action [3]. However, when taken together, they can increase the risk of serious side effects such as hypertension, seizures, and serotonin syndrome [4]. This is because ibuprofen can inhibit the metabolism of MAOIs, leading to increased levels of MAOIs in the body [5].
It is important to note that the interaction between ibuprofen and MAOIs may not be immediate, and the severity of the interaction can vary depending on several factors, including the dose of each drug, the duration of use, and individual patient characteristics [6]. Therefore, it is crucial to consult a healthcare provider before taking Advil or any other NSAID while on MAOI therapy.
In summary, Advil (ibuprofen) can affect the potency of MAOI inhibiting drugs by increasing their levels in the body, leading to an increased risk of serious side effects. It is essential to consult a healthcare provider before taking Advil or any other NSAID while on MAOI therapy.
Sources:
[1] "Monoamine Oxidase Inhibitors (MAOIs)." Mayo Clinic, Mayo Foundation for Medical Education and Research, 21 Jan. 2021, <https://www.mayoclinic.org/diseases-conditions/depression/in-depth/monoamine-oxidase-inhibitors/art-20043941>.
[2] "Ibuprofen." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, <https://medlineplus.gov/druginfo/meds/a682035.html>.
[3] "Ibuprofen." DrugPatentWatch.com, <https://www.drugpatentwatch.com/drugs/ibuprofen>.
[4] "Monoamine Oxidase Inhibitors (MAOIs)." Cleveland Clinic, <https://my.clevelandclinic.org/health/drugs/14453-monoamine-oxidase-inhibitors-maois>.
[5] "Ibuprofen and MAOIs." Drugs.com, <https://www.drugs.com/drug-interactions/ibuprofen-and-maois-ibuprofen-and-monoamine-oxidase-inhibitors-13-10-151-187-201-265-201-265.html>.
[6] "Ibuprofen and MAOIs." RxList, <https://www.rxlist.com/ibuprofen_and_maois/druginteractions.htm>.