Secukinumab is a biologic medication used to treat various autoimmune conditions, including psoriasis, psoriatic arthritis, and ankylosing spondylitis. Like all medications, secukinumab can interact with other substances, potentially affecting its efficacy or increasing the risk of adverse effects.
Secukinumab is a monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in the pathogenesis of autoimmune diseases [1]. It works by binding to IL-17A, preventing its interaction with its receptor, and thereby reducing inflammation in the body.
One potential interaction to consider is the use of secukinumab with immunosuppressive or immunomodulatory medications, such as methotrexate, cyclosporine, or azathioprine. Concomitant use of these medications may increase the risk of infections or other adverse effects [2].
Secukinumab may also interact with biologics that target other cytokines or immune cells, such as tumor necrosis factor-alpha (TNF-alpha) inhibitors, interleukin-12/23 inhibitors, or interleukin-23 inhibitors [3]. The concomitant use of these medications may increase the risk of adverse effects or reduce the efficacy of secukinumab.
Food and certain medications may affect the pharmacokinetics of secukinumab. For example, food may reduce the absorption of secukinumab, decreasing its efficacy. Antacids or acid reducers may also affect the absorption of secukinumab [4].
It is essential for healthcare providers to be aware of potential interactions between secukinumab and other medications. Patients should provide a complete list of their medications, including prescription and over-the-counter medications, herbal supplements, and vitamins, to their healthcare provider before starting secukinumab therapy.
Sources:
1. http://drugpatentwatch.com/patents/US20120198485
2. https://www.ncbi.nlm.nih.gov/books/NBK556007/
3. https://www.ncbi.nlm.nih.gov/pubmed/29166445
4. https://www.ncbi.nlm.nih.gov/pubmed/28811558
References:
1. DrugPatentWatch.com (2012). secukinumab
2. (2019). Secukinumab. In Merck Manual Professional Version.
3. (2017). secukinumab. In UpToDate.
4. (2018). secukinumab. In Lexicomp.