Benzonatate is a non-narcotic cough suppressant [1]. It works by numbing the stretch receptors in the lungs and chest walls, which helps to reduce the cough reflex [1].
How does Benzonatate work?
Benzonatate acts peripherally to suppress the cough reflex [1]. It is thought to work by anesthetizing stretch receptors located in the lungs and pleura, thereby reducing the afferent impulses that initiate the cough reflex [2]. Unlike opioid cough suppressants, it does not act on the central nervous system's cough center [3].
What is Benzonatate used for?
Benzonatate is used to relieve cough [1]. It is typically prescribed for temporary relief of bothersome coughs that do not respond to other treatments or when other treatments are not suitable [4].
What are the side effects of Benzonatate?
Common side effects of Benzonatate can include drowsiness, headache, dizziness, constipation, nausea, and rash [1]. More serious side effects, though rare, can occur. Ingestion of the capsules by children has led to severe adverse events, including seizures, cardiac arrest, and death [5]. Therefore, it is crucial that Benzonatate capsules are not chewed or dissolved in the mouth, as this can cause local anesthesia of the oral mucosa and choking [5].
When does Benzonatate patent expire?
Information regarding specific patent expirations for Benzonatate is not readily available in the provided context. Drug patent information can be complex and is tracked by specialized databases [6].
Are there alternatives to Benzonatate?
Yes, there are alternative cough suppressants available. These include prescription medications and over-the-counter (OTC) options. Opioid antitussives like codeine and hydrocodone are potent cough suppressants, but they carry risks of dependence and side effects [3]. Dextromethorphan is a common OTC cough suppressant that works centrally on the brain's cough reflex [3]. Other approaches may involve addressing the underlying cause of the cough, such as allergies, asthma, or infections, with specific treatments [4].
What is the typical dosage for Benzonatate?
The typical dosage for adults is one 100 mg capsule three times a day as needed [1]. For severe cough, the dosage may be increased to 200 mg three times a day [1]. It is important to swallow the capsules whole without chewing or crushing them [5].
Sources:
1. https://www.nih.gov/news-events/news-releases/nih-sponsored-drug-shortage-list-new-items
2. https://www.drugbank.ca/drugs/benzontate
3. https://www.nhs.uk/medicines/codeine-and-other-cough-medicines/
4. https://www.mayoclinic.org/symptoms/cough/diagnosis-treatment/drc-20351584
5. https://www.fda.gov/consumers/consumer-updates/cough-syrup-stew-potential-dangers-and-what-you-can-do
6. https://drugpatentwatch.com/