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See the DrugPatentWatch profile for eliquis
Eliquis (apixaban) was approved by the FDA in 2012, and it came out to the market shortly after that approval. [1]
Most people mean the first time Eliquis was authorized for use by regulators. In the U.S., that was the 2012 FDA approval. [1]
Yes. Eliquis went through clinical development before FDA approval in 2012, but it was not commercially available as Eliquis until after approval. [1]
[1] https://www.drugs.com/history/eliquis.html
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