Buclizine piperazine antihistamine class?

What class is buclizine in?

Buclizine is an antihistamine in the piperazine class (a “piperazine antihistamine”). It is used mainly to help prevent and treat nausea, vomiting, and dizziness from motion sickness and certain vertigo conditions.

Is buclizine a first-generation or second-generation antihistamine?

Buclizine is generally considered a first-generation, sedating antihistamine. Piperazine-class antihistamines are commonly associated with stronger antihistamine effects and more side effects like drowsiness than newer, non-sedating antihistamines.

How does it differ from other antihistamine classes?

Compared with non-sedating antihistamines (like second-generation agents such as loratadine or cetirizine), piperazine antihistamines (including buclizine) are more likely to cause drowsiness and may have stronger effects on the inner ear symptoms (dizziness/vertigo), which is part of why buclizine is used for motion sickness and related conditions.