Nifedipine moa?

Nifedipine’s Mechanism of Action (MOA)

- Drug class: Dihydropyridine calcium‑channel blocker.
- Primary target: L‑type voltage‑gated Ca²⁺ channels (VGCCs) in vascular smooth‑muscle cells.
- What it does:
1. Blocks Ca²⁺ entry when the membrane depolarizes.
2. Reduces intracellular Ca²⁺ concentration → less actin–myosin cross‑bridge formation.
3. Causes smooth‑muscle relaxation → vasodilation of arterioles.
- Resulting hemodynamic effect: ↓ systemic vascular resistance → ↓ preload & afterload → lower blood pressure and reduced myocardial oxygen demand.

Secondary actions:
- Minor effects on cardiac conduction (prolongs QT in high doses).
- Used mainly for hypertension, angina, and certain arrhythmias.

In short, nifedipine blocks L‑type Ca²⁺ channels, preventing Ca²⁺ influx into vascular smooth muscle, leading to vasodilation and blood‑pressure lowering.