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See the DrugPatentWatch profile for cosentyx
How does Cosentyx perform against Humira in head-to-head trials? Head-to-head data from the SURPASS study showed Cosentyx achieving 66% PASI 90 at week 16 versus Humira's 50%, with similar results persisting through week 52. [1] What drives the difference in skin clearance rates? Cosentyx blocks IL-17A alone, while Humira targets TNF-alpha. The cytokines sit upstream or downstream in the inflammatory pathway, so targeting IL-17A directly produces higher skin-clearance scores in plaque psoriasis patients. [1] What happens when patients switch from Humira to Cosentyx? Switching after inadequate response to TNF inhibitors lifts PASI 90 rates to 48% by week 16, with 71% of patients reaching PASI 75. [2] Can Cosentyx keep working after Humira stops? Cosentyx keeps working when Humira fails, showing continued improvement across multiple joint and skin endpoints in TNF-inadequate responders. [2] When does Cosentyx lose exclusivity? Cosentyx holds exclusivity until at least 2025 in the U.S., with primary U.S. patents expiring 2025–2029. [3] What company makes Cosentyx? Novartis manufactures Cosentyx. [3]
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