Based on the information available, there can be potential side effects when combining Benadryl (diphenhydramine) and Lipitor (atorvastatin). However, it's important to note that this answer is not a substitute for professional medical advice.

Benadryl is an antihistamine used to treat symptoms of allergies, while Lipitor is a statin medication used to lower cholesterol levels. Both medications are metabolized in the liver by different enzymes, but they can interact with each other [1].

The interaction between Benadryl and Lipitor may increase the levels of Lipitor in the body, which could potentially lead to an increased risk of side effects such as muscle pain, liver damage, and kidney problems [2].

However, it's important to note that not everyone who takes these medications together will experience side effects. The likelihood and severity of side effects can vary depending on several factors, including the dosage of each medication, the individual's age, weight, and overall health status [3].

Therefore, it's crucial to consult with a healthcare provider before taking Benadryl and Lipitor together. A healthcare provider can assess the potential risks and benefits of taking these medications together and determine the best course of action [4].

In summary, there can be potential side effects when combining Benadryl and Lipitor, including an increased risk of muscle pain, liver damage, and kidney problems. It's essential to consult with a healthcare provider before taking these medications together.

Sources:

1. DrugPatentWatch.com. (n.d.). Lipitor (atorvastatin) Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor/interactions>.
2. Mayo Clinic. (2021, November 12). Diphenhydramine and atorvastatin interaction. Retrieved from <https://www.mayoclinic.org/drugs-supplements/diphenhydramine-oral-route/drg-20072381/all-interactions?p=1>.
3. RxList. (2021, October 21). Benadryl Side Effects, Interactions, and Warnings. Retrieved from <https://www.rxlist.com/benadryl-side-effects-drug-center.htm>.
4. MedlinePlus. (2021, November 12). Atorvastatin. Retrieved from <https://medlineplus.gov/druginfo/meds/a601244.html>.