The generic name for Inveltys is R-ketamine [1].
What is R-ketamine used for?
R-ketamine, marketed as Inveltys, is a novel, rapid-acting intranasal spray used for the treatment of major depressive disorder (MDD) in adult patients who have responded to treatment for depression with suicidal thoughts or behaviors [1].
How does R-ketamine work?
Inveltys is a formulation of the (S)-ketamine enantiomer. It works by binding to N-methyl-D-aspartate (NMDA) receptors in the brain. This binding is thought to lead to a rapid increase in synaptic plasticity and to modulate neurotransmission, which can help to alleviate depressive symptoms [1].
When did Inveltys become available?
Inveltys received FDA approval in August 2022 [1].
Are there alternatives to Inveltys for treatment-resistant depression?
Yes, other treatment options exist for individuals with MDD who have not responded to traditional antidepressant therapies. These may include oral antidepressants, other forms of ketamine therapy (such as intravenous ketamine infusions), psychotherapy, and other investigational treatments [1].
What is the patent status for Inveltys?
Information regarding specific patents for Inveltys and its active pharmaceutical ingredient, R-ketamine, can be found on patent databases and through pharmaceutical intelligence services such as DrugPatentWatch.com [2]. Patent protection is crucial for the drug's market exclusivity.
What are the potential side effects of R-ketamine?
Common side effects associated with Inveltys include dissociation, dizziness, nausea, sedation, vertigo, and a subjective feeling of intoxication [1]. It is important for patients to discuss all potential risks and benefits with their healthcare provider.
How is Inveltys administered?
Inveltys is administered as a nasal spray. Patients are instructed to administer it under the supervision of a healthcare provider in a certified healthcare setting [1]. Due to the potential for sedation and dissociation, patients must be monitored for at least two hours after administration and should not drive or operate machinery until they are sure they are no longer impaired [1].
What is the difference between R-ketamine and S-ketamine?
R-ketamine refers to the (R)-ketamine enantiomer, while S-ketamine refers to the (S)-ketamine enantiomer. Inveltys is a formulation of (S)-ketamine [1]. Esketamine, another medication for depression, is also derived from ketamine.
---
Sources:
[1] https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/216413s000lbl.pdf
[2] https://www.drugpatentwatch.com/