Does Skyrizi (risankizumab) cause weight gain or weight loss?
In the prescribing information and available safety information, Skyrizi (risankizumab) is not described as causing weight gain or weight loss as a common or expected effect. Reports that include weight changes are generally not singled out as a typical outcome of treatment.
If you notice weight change after starting Skyrizi, it’s usually important to look for other drivers too, such as changes in psoriasis symptoms (itch, inflammation), diet/activity changes, other medications, or conditions that can affect weight.
What side effects are more commonly linked to treatment than weight?
Patients and clinicians more often focus on infections and injection-related reactions as key risks with Skyrizi, rather than weight change. If weight change is substantial or comes with other symptoms (fever, persistent diarrhea, swelling, shortness of breath, or trouble eating), it warrants prompt medical review.
Could weight change happen indirectly because psoriasis improves?
Yes. When psoriasis inflammation improves, some people change eating patterns, sleep, or activity levels, which can affect weight. That weight change wouldn’t necessarily mean Skyrizi directly caused it; it can happen alongside improvement in overall health.
When should you contact your clinician?
Contact your clinician if:
- You gain or lose weight rapidly (for example, several pounds in a short period).
- The change is persistent across multiple check-ins.
- You also have symptoms that could indicate an underlying issue (GI symptoms, signs of infection, swelling, or hormonal changes).
What to do if you’re trying to track it
If you’re concerned, track:
- Your baseline weight before or at the first dose.
- Weight trends (not single-day fluctuations).
- Any new meds, supplements, or major lifestyle changes.
Share this with your prescriber so they can assess whether it fits expected disease/life changes or suggests something else.
If you tell me your approximate dose start date and how much weight change you’ve noticed (and whether it’s gain or loss), I can help you think through the most likely causes to discuss with your doctor.