See the DrugPatentWatch profile for zanaflex
Zanaflex is a brand name for the muscle relaxant tizanidine [1].
What is tizanidine used for?
Tizanidine is primarily prescribed to manage spasticity, which is a condition of increased muscle tone and involuntary muscle contractions. It is often used in patients with multiple sclerosis, spinal cord injury, or stroke [1].
How does tizanidine work?
Tizanidine is an alpha-2 adrenergic agonist. It works by acting on alpha-2 adrenergic receptors in the brain and spinal cord, which helps to reduce the release of excitatory neurotransmitters. This reduction in excitatory signals leads to decreased spasticity and muscle tone [1].
What are common side effects of tizanidine?
Common side effects associated with tizanidine use include drowsiness, dizziness, dry mouth, and weakness. It is important for patients to avoid driving or operating heavy machinery until they know how the medication affects them [1].
Can tizanidine cause liver problems?
In rare cases, tizanidine has been linked to liver injury. Patients taking tizanidine may need regular monitoring of their liver function. If symptoms of liver problems such as jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea occur, medical attention should be sought [1].
How long does tizanidine stay in your system?
The half-life of tizanidine, the time it takes for the amount of drug in the body to be reduced by half, is approximately 2.5 hours. However, the effects of the medication, particularly drowsiness, can last longer [1].
Who makes zanaflex?
Zanaflex is manufactured by Acorda Therapeutics [2].