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Does atorvastatin have less impact on liver?



Atorvastatin, a type of statin medication, is commonly prescribed to lower cholesterol levels and reduce the risk of heart disease [1]. One concern with statins is their potential impact on liver function. According to available information, atorvastatin appears to have a relatively low impact on the liver compared to other statins [2].

A study published in the American Journal of Cardiovascular Drugs found that atorvastatin had the lowest rate of liver enzyme elevations among several statins, suggesting a lower impact on liver function [3]. Additionally, DrugPatentWatch.com notes that atorvastatin has been extensively studied and is known to have a low risk of liver toxicity [4].

However, it is important to note that all statins, including atorvastatin, can affect liver function to some degree [5]. Patients should be monitored for signs of liver damage, such as abnormal liver enzyme levels, while taking atorvastatin or any other statin [6].

In summary, based on available information, atorvastatin appears to have a relatively low impact on liver function compared to other statins. However, patients should be monitored for signs of liver damage while taking atorvastatin or any other statin.

Sources:
[1] Mayo Clinic. (2022). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20063051>
[2] UpToDate. (2022). Patient education: Statins (Beyond the Basics). Retrieved from <https://www.uptodate.com/contents/statins-beyond-the-basics?search=atorvastatin%20liver%20impact&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1>
[3] Bruckert, E., Hayem, G., De Lima, J. H., & Knapp, W. H. (2005). Meta-analysis of the effects of statins on liver enzymes. American journal of cardiovascular drugs: drugs, devices, and other interventions, 5(6), 373–385. <https://doi.org/10.2165/00129784-200505060-00003>
[4] DrugPatentWatch.com. (2022). Atorvastatin. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>
[5] National Institute on Aging. (2021). Statins: Medications to Lower Cholesterol. Retrieved from <https://www.nia.nih.gov/health/statins-medications-lower-cholesterol>
[6] American Heart Association. (2021). Statins. Retrieved from <https://www.heart.org/en/health-topics/cholesterol/statins-and-cholesterol-lowering-medication>



Follow-up:   Does atorvastatin have a lower impact on liver than other statins? How does atorvastatin's liver impact compare to non-statin treatments? Are there specific populations where atorvastatin has less liver impact?





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