Based on the information available, Tigecycline, a broad-spectrum antibiotic, is not known to specifically affect particular liver enzymes. It is metabolized in the liver, but it does not typically cause liver enzyme abnormalities [1]. However, like other antibiotics, Tigecycline can cause mild to moderate increases in liver enzymes, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but these are not specific to Tigecycline and can occur with many other medications [2].

It is important to note that patients with severe hepatic impairment should be closely monitored when receiving Tigecycline, as the drug's pharmacokinetics may be altered in these individuals [3].

In summary, while Tigecycline can cause mild to moderate increases in liver enzymes, it does not specifically affect particular liver enzymes.

Sources:
[1] DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>
[2] UpToDate. (2021). Tigecycline: Drug information. Retrieved from <https://www.uptodate.com/contents/tigecycline-drug-information>
[3] FDA. (2010). Tygacil (tigecycline) injection, for intravenous use. Retrieved from <https://www.fda.gov/media/74361/download>