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See the DrugPatentWatch profile for entresto
Entresto (sacubitril/valsartan) has a dual mechanism of action: - Sacubitril inhibits neprilysin, which increases levels of natriuretic peptides and other vasoactive substances. - Valsartan blocks the angiotensin II type 1 (AT1) receptor, reducing the effects of angiotensin II on blood vessels and aldosterone release. Together, this combination shifts signaling toward natriuresis (more salt/water excretion), vasodilation, and reduced RAAS (renin-angiotensin-aldosterone system) activity.
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