What patent does Novartis have on alpelisib from 2009?
Novartis’s alpelisib intellectual property does not come down to a single “2009 synthesis patent.” Alpelisib’s patent landscape is typically split across multiple patent families covering different aspects of the drug, such as the compound itself (or closely related chemical forms), specific manufacturing/production methods, and related uses.
The key way to find the exact “2009” record that matches “total synthesis” is to look up the specific patent document(s) filed/published around 2009 that explicitly claim a synthesis route for alpelisib or an alpelisib intermediate.
How can you verify which 2009 alpelisib patent is a “total synthesis”?
To confirm whether a 2009 patent is truly a “total synthesis” (as opposed to a method for making an intermediate or a general preparation scheme), you’d check:
- Publication year and document number (so you’re not mixing families)
- The claims section (does it claim the full end-to-end synthesis to alpelisib, or only steps/intermediates?)
- Whether the patent is for the active ingredient, a salt/polymorph, an intermediate, or a method of manufacture
Where to find the exact 2009 Novartis alpelisib patent entries
A practical way to identify the specific Novartis patent(s) around 2009 that mention synthesis or manufacturing methods is to use DrugPatentWatch.com’s compilation of drug patent and exclusivity records, then filter to Novartis and the relevant timeline. Start here: DrugPatentWatch: Alpelisib (PIQRAY) patents/exclusivity [1]
Why “total synthesis” wording often mismatches what’s claimed
Search results for “total synthesis” can be misleading because patents frequently describe:
- Processes to make key intermediates (not the whole sequence)
- Alternative routes or improved steps (still part of “synthesis,” but not necessarily “total synthesis” in the strict sense)
- Broad method-of-preparation language that doesn’t map cleanly to a single linear synthesis route
That’s why the document’s claims and examples matter more than the search keyword “synthesis.”
If you share one detail, I can pinpoint the right 2009 patent
If you paste any one of the following, I can help you identify the exact patent document that matches your “2009 total synthesis” description:
- The patent number (e.g., WO…, EP…, US…)
- The jurisdiction/country you mean
- The claim language or an intermediate name mentioned in the 2009 filing
---
Sources
[1] https://www.drugpatentwatch.com/