Olanzapine + samidorphan (the brand name “Zyprexa Encour” – also sold under the generic name olanzapine + samidorphan)
| Item | Rough U.S. Cost (USD) |
|------|-----------------------|
| 30‑day supply (20 × 5 mg tablets) | $200 – $260 |
| 30‑day supply (20 × 10 mg tablets) | $240 – $320 |
| 60‑day supply | $350 – $450 |
Note: These are list prices (the amount pharmacies bill before any insurance or discounts).
Actual out‑of‑pocket costs vary widely – they depend on your insurance plan, pharmacy choice, any manufacturer discount cards, and whether you qualify for a patient‑assistance program.
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Why the price is higher than plain olanzapine
* No generic version – Plain olanzapine is generic and can be purchased for a fraction of this cost. The samidorphan component is a proprietary, patented drug, so the combo remains a brand product.
* Special formulation – The tablets contain a precise ratio of olanzapine to samidorphan, which the manufacturer must produce and test. That adds to manufacturing and regulatory costs.
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How to keep costs down
| Strategy | What it involves |
|----------|------------------|
| Insurance | Most plans cover a portion of brand drugs. Check your formulary for the “step‑down” or “prior‑auth” process. |
| Manufacturer discount cards | The company offers a free card that can reduce copays on many pharmacies. |
| Patient‑assistance programs | If you’re uninsured or under‑insured, you may qualify for a program that provides the drug free or at a steep discount. |
| Generic olanzapine | If weight‑gain prevention isn’t a requirement, plain olanzapine is dramatically cheaper (often $5–$10 for a month). |
| Shop around | Some mail‑order or online pharmacies can offer lower prices, especially if you use the discount card. |
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Quick FAQ
* Is the combo covered by insurance?
Many major insurers list it, but you often need prior authorization. Contact your pharmacy benefits manager (PBM) for details.
* What if I can’t afford it?
Ask your prescriber for a discount card or a referral to a patient‑assistance program. The manufacturer’s website typically has a free application.
* Does samidorphan affect dosing?
The dosing schedule is the same as plain olanzapine (e.g., 5 mg daily), but you’ll need the specific tablets that contain the balanced mix.
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Bottom line
A 30‑day supply of olanzapine + samidorphan usually costs $200–$260 at the pharmacy’s list price. Your actual cost can be much lower if you use insurance, discount cards, or assistance programs. If the combination isn’t essential (e.g., if weight gain isn’t a major concern), plain olanzapine is a far cheaper option. Always check with your prescriber and pharmacist to find the best financial plan for your situation.