Griseofulvin microsize is an oral antifungal medication used to treat fungal infections of the skin, hair, and nails [1]. It works by disrupting the fungal cell's ability to divide and by binding to microtubules, which are essential for cell structure and function [2].
How does griseofulvin microsize work?
Griseofulvin microsize is absorbed from the gastrointestinal tract and then deposited in the keratin-containing tissues, such as skin, hair, and nails [2]. It is incorporated into the keratin structure as it is formed, making the new growth resistant to fungal invasion [2]. The drug does not kill fungi directly but prevents them from growing and multiplying [2].
What conditions does griseofulvin microsize treat?
This medication is effective against a range of dermatophytes, which are fungi that cause infections like ringworm (tinea) of the scalp, body, feet, and nails [1]. It is particularly used for stubborn or widespread infections that haven't responded to topical treatments [3].
When does griseofulvin microsize treatment end?
Treatment duration with griseofulvin microsize can vary, but it typically lasts from two to six weeks for skin and hair infections, and up to six months or longer for nail infections, as new nail growth replaces the infected tissue [3].
Are there different forms of griseofulvin?
Yes, griseofulvin is available in two formulations: microsize and ultramicrosize [4]. The ultramicrosize form is absorbed more readily by the body, potentially requiring a lower dose for similar effectiveness [4].
What are the potential side effects of griseofulvin microsize?
Common side effects include headache, nausea, vomiting, diarrhea, dizziness, and skin rash [1]. Less common but more serious side effects can include liver problems, severe skin reactions, and blood disorders [1]. Patients should consult their doctor if they experience persistent or severe side effects [1].
What about drug interactions with griseofulvin microsize?
Griseofulvin microsize can interact with certain medications, notably by reducing the effectiveness of oral contraceptives and increasing the effects of anticoagulants [1]. It can also interact with drugs that affect liver enzymes, which may alter griseofulvin levels [5].
What is the patent status for griseofulvin?
Griseofulvin was first patented many decades ago, and its original patents have long expired [6]. Consequently, generic versions of griseofulvin microsize are widely available [6].
Who manufactures generic griseofulvin microsize?
Several pharmaceutical companies produce generic versions of griseofulvin microsize. Information on specific manufacturers and their product availability can often be found through drug compendia and pharmaceutical databases.
Sources
1. https://www.nhs.uk/medicines/griseofulvin/
2. https://www.msdmanuals.com/home/infections/antifungal-medications/griseofulvin
3. https://www.drugs.com/griseofulvin.html
4. https://www.ncbi.nlm.nih.gov/books/NBK459297/
5. https://medlineplus.gov/druginfo/meds/a682049.html
6. https://drugpatentwatch.com/