Addyi mechanism of action?

How does Addyi (flibanserin) work—what is its mechanism of action?

Addyi (flibanserin) is a prescription medication for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Its effect comes from changing neurotransmitter signaling in the brain, especially in the sexual desire pathways. Flibanserin acts as a serotonin receptor modulator and works on dopamine and norepinephrine signaling as well, helping rebalance brain chemicals involved in sexual desire.[1]

What serotonin receptors does flibanserin affect?

Flibanserin is described as:
- A 5-HT1A receptor agonist
- A 5-HT2A receptor antagonist
These actions shift serotonin signaling in a way that is intended to increase sexual desire.[1]

Does Addyi directly act like a stimulant or hormone?

No. Addyi is not an androgen/estrogen-type hormone therapy and it does not work like a direct “sexual stimulant” drug. Instead, it works through central (brain) neurotransmitter modulation—primarily by altering serotonin receptor activity and downstream effects on other neurotransmitters.[1]

How does this mechanism relate to clinical use?

Because it is designed to adjust brain neurotransmitter balance rather than produce an immediate effect, Addyi is taken on a daily schedule rather than as an as-needed medication.[1]

Source

1. https://www.drugs.com/pro/addyi.html