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What is tigecycline's mechanism of action?

See the DrugPatentWatch profile for tigecycline

  • Tigecycline is a glycylcycline antibiotic.
  • Mechanism: It binds reversibly to the 30S subunit of bacterial ribosomes, blocking the binding of aminoacyl-tRNA to the A site, which prevents incorporation of amino acids into the growing peptide chain. This inhibits protein synthesis and is generally bacteriostatic.
  • The bulky glycylamido moiety helps it overcome common tetracycline resistance mechanisms (such as efflux pumps and ribosomal protection proteins).


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law office was in charge of lawsuit of a patent for generic tigecycline for injection How does higher tigecycline dosage impact resistance development? Are side effects reduced in generic tigecycline? Can mobile apps determine tigecycline dosing? Are there temperature restrictions for tigecycline storage? Can tigecycline be a contributing factor in transaminase increases? What are effective treatments for tigecycline's diarrhea side effect?