Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class. It is used to treat pain and inflammation associated with osteoarthritis and rheumatoid arthritis [1].
How does meloxicam work?
Meloxicam functions by inhibiting cyclooxygenase (COX) enzymes, specifically COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing prostaglandin synthesis, meloxicam helps to alleviate these symptoms [1].
What forms of meloxicam are available?
Meloxicam is available in several forms, including oral tablets, oral suspension, and injectable solutions [2].
When does meloxicam lose patent protection?
The patent protection for meloxicam has largely expired, allowing for the availability of generic versions. The original U.S. patent for meloxicam expired in 2011 [3].
Can you buy meloxicam over-the-counter?
In many regions, including the United States, meloxicam is available by prescription only [2].
What are the common side effects of meloxicam?
Common side effects reported with meloxicam use include gastrointestinal issues such as nausea, diarrhea, indigestion, and abdominal pain. Other potential side effects include dizziness, headache, and rash [2].
What are the risks associated with NSAIDs like meloxicam?
Like other NSAIDs, meloxicam carries risks of serious cardiovascular thrombotic events, myocardial infarction, and stroke. It can also increase the risk of gastrointestinal bleeding, ulceration, and perforation. Patients with pre-existing cardiovascular disease or risk factors are at higher risk [2].
How does meloxicam compare to other NSAIDs?
Meloxicam is considered a preferential COX-2 inhibitor, meaning it has a higher affinity for COX-2 than COX-1. This mechanism is intended to reduce the gastrointestinal side effects commonly associated with less selective NSAIDs that inhibit both COX enzymes [1].
Are there alternatives to meloxicam for arthritis pain?
Alternatives to meloxicam for arthritis pain management may include other NSAIDs, acetaminophen, corticosteroid injections, and disease-modifying antirheumatic drugs (DMARDs), depending on the specific type and severity of arthritis [4].
What is the typical dosage for meloxicam?
Dosage for meloxicam varies depending on the condition being treated and the patient's response. For osteoarthritis, a common starting dose is 7.5 mg once daily, which may be increased to 15 mg once daily [2].
Sources:
1. https://www.drugpatentwatch.com/generic-drug-list/meloxicam
2. https://www.webmd.com/drugs/2/drug-1529/meloxicam-oral/details
3. https://www.drugpatentwatch.com/drug/meloxicam
4. https://www.mayoclinic.org/diseases-conditions/arthritis/diagnosis-treatment/drc-20350515