How to Inject Kevzara
Kevzara (sarilumab) is injected subcutaneously (under the skin) once every 2 weeks using a prefilled syringe or autoinjector. Common sites include the thigh, abdomen (at least 2 inches from the navel), or upper arm (with help). Do not inject into tender, bruised, scarred, or hard skin.
1. Wash hands and clean injection site with alcohol swab.
2. Let device warm to room temperature (30 minutes out of fridge).
3. For syringe: Pinch skin, insert needle at 45-90 degree angle, push plunger slowly.
4. For autoinjector: Place yellow cap side down on skin, press button until it clicks twice (yellow indicator shows).
5. Hold for 10 seconds after injection; needle retracts automatically in autoinjector.
6. Dispose of used device in sharps container.[1][2]
Dosage for Rheumatoid Arthritis
Adults: 200 mg every 2 weeks. Reduce to 150 mg if neutrophils <2000/mm³, platelets <150,000/mm³, ALT/AST >2x upper limit, or serious infection. Lowest effective dose for some patients. Pediatrics (1-17 years, ≥63 kg): Weight-based, starting at 2 mg/kg every 2 weeks.[1][2]
Preparing for Your First Dose
Doctor or nurse demonstrates first injection. Rotate sites. Store in fridge (36-46°F); protect from light. Can refrigerate up to 3 days after first use. Check expiration and inspect for damage/particles.[1][2]
What If I Miss a Dose?
Inject as soon as possible if within days of schedule, then resume every 2 weeks. Do not double dose.[1]
Side Effects Patients Report
Common: Injection site reactions (redness, itching), upper respiratory infections, sore throat, runny nose, fever, abnormal liver tests. Serious risks: Infections (TB, fungal), low neutrophils/platelets, GI tears, liver damage, cancer risk. Stop if serious infection or low blood counts; monitor labs regularly. Avoid live vaccines.[1][2]
Who Should Not Use Kevzara
Active infections, low neutrophils/platelets, liver disease, pregnancy (may harm fetus; use contraception), breastfeeding (unknown risk). Screen for TB/hepatitis before starting.[1]
Storage and Travel Tips
Refrigerate unopened. For travel: Use cooler pack; stable at room temp <77°F up to 3 days. Keep instructions handy.[1]
Sources
[1]: Kevzara Prescribing Information (FDA)
[2]: Kevzara Patient Instructions for Use