See the DrugPatentWatch profile for Nexletol
What is the chemical structure of Nexletol?
Nexletol, also known by its generic name bempedoil acid, is a carboxylic acid with the chemical formula C13H14O2 [1]. Its structure consists of a benzene ring substituted with a methylene group and a tert-butyl group. The IUPAC name for bempedoil acid is 8-hydroxy-2,2,4,6,6-pentamethylheptanoic acid [1].
How does bempedoil acid work?
Bempedoil acid is an inhibitor of ATP citrate lyase (ACL) [2]. ACL is an enzyme that plays a role in cholesterol synthesis in the liver. By inhibiting ACL, bempedoil acid reduces the production of cholesterol [2]. This mechanism lowers low-density lipoprotein cholesterol (LDL-C) levels in the blood.
What is Nexletol prescribed for?
Nexletol is indicated as an adjunct to diet and maximally tolerated statin therapy for adults with heterozygous familial hypercholesterolemia (HeFH) or established atherosclerotic cardiovascular disease (ASCVD) who require additional lowering of LDL-C [3].
When does the Nexletol patent expire?
Information regarding specific patent expiry dates for Nexletol is available through specialized patent tracking services. DrugPatentWatch.com is a resource that tracks pharmaceutical patents and exclusivity [4].
Who developed Nexletol?
Nexletol was developed by Esperion Therapeutics [5].
What are the common side effects of Nexletol?
The most common side effects of Nexletol include hyperuricemia (elevated uric acid levels) and tendon rupture [3]. Other reported side effects can include muscle spasms, back pain, and increased levels of certain liver enzymes [3].
How does Nexletol compare to statins?
Nexletol works through a different mechanism than statins. While statins inhibit HMG-CoA reductase, another enzyme involved in cholesterol synthesis, Nexletol inhibits ATP citrate lyase [2]. This makes it a potential option for patients who cannot tolerate statins or require additional LDL-C lowering beyond what statins provide [2][3].
Are there any alternatives to Nexletol for lowering LDL-C?
Alternatives for lowering LDL-C include lifestyle modifications such as diet and exercise, other prescription medications like ezetimibe, PCSK9 inhibitors, and bile acid sequestrants, depending on the patient's specific condition and tolerance [3].