Can you take a live virus vaccine while on Cosentyx (secukinumab)?
Cosentyx (secukinumab) is a biologic that blocks interleukin-17A (IL-17A). Because it affects immune signaling, people taking Cosentyx generally should not receive live (attenuated) vaccines unless their clinician specifically approves it. Live vaccines are designed to replicate in the body and can pose a higher risk when the immune system is suppressed.
What counts as a “live virus vaccine”?
Live virus vaccines include weakened forms of viruses (and some are given by nasal spray or injection). Examples commonly listed in patient guidance include:
- Live influenza vaccine given as a nasal spray (not the inactivated flu shot)
- Measles-mumps-rubella (MMR)
- Varicella (chickenpox)
- Live zoster (zoster vaccine types vary; the commonly used option for immunocompromised adults is usually the non-live recombinant formulation)
If you tell your clinician the exact vaccine name (or vaccine brand), they can confirm whether it is live and whether it is appropriate with Cosentyx.
What vaccines are usually preferred instead?
Inactivated (non-live) vaccines are generally the preferred option for people on immunomodulating therapies like Cosentyx. Many seasonal vaccines (like the inactivated flu shot) are non-live. The exact timing can still matter, so it’s best to coordinate with the prescribing doctor and the vaccine provider.
When is it safest to get vaccines if you might start or stop Cosentyx?
Clinicians often try to complete needed vaccinations before starting immunosuppressive biologic therapy, when possible. If you already take Cosentyx, the safest approach is usually:
- Avoid live vaccines unless your specialist says otherwise
- Use non-live vaccine alternatives when available
- Plan timing around your treatment schedule based on your individual risk
What should you do before getting a vaccine?
Ask:
1. Is this vaccine live or inactivated?
2. Does my Cosentyx dose and schedule affect whether I can get it?
3. Should I pause Cosentyx, and if so, for how long (only your prescriber can advise)?
4. Do I need any catch-up vaccines given my age and conditions?
Your rheumatologist/dermatologist (the prescriber for Cosentyx) is the right authority to approve any live vaccine.
When to seek urgent medical advice
If you receive a live vaccine while on Cosentyx (or shortly before starting), contact your prescriber promptly for guidance. Also seek medical advice urgently if you develop symptoms consistent with the infection the vaccine was intended to prevent.
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