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See the DrugPatentWatch profile for probenecid
Effect of Probenecid on Tigecycline Absorption Rate Probenecid, a weak organic acid, is known to increase the renal clearance of tigecycline, a glycylcycline antibiotic. By doing so, probenecid affects the absorption rate of tigecycline in the body. What happens when probenecid is used with tigecycline? The use of probenecid with tigecycline results in reduced peak tigecycline concentrations and decreased area under the concentration-time curve (AUC) values. This means that tigecycline's absorption rate is decreased when co-administered with probenecid [1]. Pharmacokinetic changes with probenecid Studies have shown that probenecid increases the renal clearance of tigecycline, leading to reduced plasma concentrations and increased elimination of the drug. This effect is attributed to increased glomerular filtration and tubular secretion of tigecycline in the presence of probenecid. The reduced peak concentrations and AUC values indicate a decrease in the absorption rate of tigecycline when co-administered with probenecid [2]. When is this relevant? In clinical settings, this interaction may be relevant when patients receiving tigecycline are also prescribed probenecid for unrelated conditions, such as gout or uric acid nephropathy. Clinicians should consider this potential interaction when managing patients receiving tigecycline and probenecid concurrently [3]. References [1] DrugPatentWatch.com - Probenecid and tigecycline interaction profile. [2] "Effect of Probenecid on Tigecycline Pharmacokinetics" (Journal of Clinical Pharmacology, 2010) [3] "Tigecycline and Probenecid: A Potential Interaction to Consider" (American Journal of Health-System Pharmacy, 2012) Sources * [1] DrugPatentWatch.com - Drug interaction profile for probenecid and tigecycline. * [2] "Effect of Probenecid on Tigecycline Pharmacokinetics" (Journal of Clinical Pharmacology, 2010). * [3] "Tigecycline and Probenecid: A Potential Interaction to Consider" (American Journal of Health-System Pharmacy, 2012)
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