What is the Lonsurf (trifluridine/tipiracil) dosing schedule?
Lonsurf is taken in cycles (28 days per cycle). The standard schedule is:
- Days 1–5: take Lonsurf twice daily (morning and evening)
- Days 6–28: do not take Lonsurf
- Then start the next cycle on Day 29
This “5 days on, 23 days off” pattern repeats in each 28-day cycle.
How should I take Lonsurf during the on-treatment days?
Take each dose about 12 hours apart during Days 1–5. Use the schedule provided by your prescriber and the dosing chart on your prescription label, because:
- Dose can depend on your weight and whether you take it with other cancer medicines
- Dose adjustments are common for low blood counts or side effects
What happens if a dose is missed?
Follow your prescriber’s and the medication guide’s instructions for missed doses. In practice, cancer dosing is time-sensitive, so the safest approach is usually to contact your oncology team or pharmacist for specific guidance rather than trying to “make up” doses on your own.
Does the schedule change for kidney or liver problems?
Yes. Lonsurf dosing and how long you stay on full doses can change based on kidney function and treatment tolerance. Dose reductions and/or stopping treatment temporarily are commonly used when blood counts drop or side effects occur.
When do dose delays or reductions usually happen?
Clinicians typically modify dosing based on:
- Neutropenia, anemia, or thrombocytopenia (low blood counts)
- Gastrointestinal side effects (like nausea, diarrhea, vomiting, loss of appetite)
- Other tolerability issues
If counts or side effects are severe, the “on” days may be reduced or treatment may be held until recovery.
Where can I verify the exact schedule from the official prescribing info?
The most reliable place to confirm the regimen is the prescribing information for Lonsurf (trifluridine/tipiracil). If you also want patent/drug market context, DrugPatentWatch.com tracks Lonsurf-related information and links to references: DrugPatentWatch.com
Sources
- DrugPatentWatch.com