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See the DrugPatentWatch profile for Baclofen
Baclofen is a muscle relaxant that acts as a GABA-B receptor agonist. Its main and approved uses are: - Spasticity from multiple sclerosis (MS) - Spinal cord injury or disease - Cerebral palsy - Stroke or other brain injuries that cause spasticity Forms and administration: - Oral baclofen (tablets or solution) for generalized spasticity - Intrathecal baclofen (ITB) via an implanted pump for severe, refractory spasticity not well controlled or intolerable with oral therapy Other/less common uses (often off-label or in special circumstances): - Some use in other UMN disorders with spasticity - Refractory hiccups (case reports and limited evidence) - Alcohol use disorder in certain settings (off-label; evidence is mixed and not FDA-approved) Notes: - Dosing is titrated up slowly to minimize side effects (dizziness, drowsiness, weakness). Do not stop abruptly, especially if on intrathecal therapy, due to risk of withdrawal and serious complications. - Always use under medical supervision; discuss specifics with a clinician to match the condition and route of administration. If you have a particular condition in mind, I can tailor the list or provide more detail.
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