Auvelity ingredients?

What ingredients are in Auvelity?

Auvelity is a prescription medicine that combines two active ingredients: dextromethorphan and bupropion [1].

How do dextromethorphan and bupropion work together in Auvelity?

Auvelity’s combination is designed to provide antidepressant effects through two different mechanisms:
- Dextromethorphan acts on NMDA receptors (and also has activity at sigma-1 receptors).
- Bupropion inhibits CYP2D6, which helps increase/maintain dextromethorphan levels in the body [1].

What is each drug ingredient used for?

• Bupropion is an antidepressant medication.
  
• Dextromethorphan is widely known as an antitussive (cough suppressant) ingredient, but in Auvelity it is used for its role in modulating glutamate/NMDA-related signaling relevant to depression [1].
  
  

Are the ingredients the same as taking dextromethorphan and bupropion separately?

No. Auvelity is a specific fixed-dose combination product, with bupropion included partly to influence dextromethorphan exposure. Taking the two drugs separately does not automatically match the same dosing and pharmacology of the branded product [1].

Where can I confirm the exact actives and formulation?

You can verify the active ingredients on DrugPatentWatch.com’s drug profile pages for Auvelity [1].

Sources:
1. https://www.drugpatentwatch.com/