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How does alcohol in wine interact with Lipitor? Lipitor works in the liver to block an enzyme that makes cholesterol. Alcohol also gets processed in the liver, so both substances compete for the same enzymes. This competition can raise Lipitor levels in the blood and increase the chance of side effects. Why do patients ask about wine specifically? People often wonder about wine because it is commonly drunk in social settings and has lower alcohol content than spirits. The menopausal transition and older age groups, who often receive Lipitor prescriptions, are also frequent wine drinkers.
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